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M9630168.TXT
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1996-02-27
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Document 0168
DOCN M9630168
TI Opportunistic infections of the central nervous system in children with
HIV infection: report of 9 autopsy cases and review of literature.
DT 9603
AU Wrzolek MA; Brudkowska J; Kozlowski PB; Rao C; Anzil AP; Klein EA; Del
Rosario C; Abdu A; Kaufman L; Chandler FW; Department of Pathology,
State University of New York Health; Science Center, Brooklyn 11203,
USA.
SO Clin Neuropathol. 1995 Jul-Aug;14(4):187-96. Unique Identifier :
AIDSLINE MED/96123602
AB Central nervous system (CNS) abnormalities attributed to direct effects
of HIV infection are seen in most of children with acquired
immunodeficiency syndrome (AIDS). Secondary CNS infections with
opportunistic and common pathogens are infrequent in this age group. We
report 9 cases of opportunistic infection of the CNS found among 65
autopsy cases of pediatric AIDS. These included 4 cases of
cytomegalovirus (CMV) infection, 1 of which was associated with
aspergillosis, and 2 cases of candidiasis, 1 of which coexisted with
Mycobacterium avium intracellulare (MAI) infection. There were also 2
cases of leptomeningitis, 1 due to Mycobacterium tuberculosis (MTB) and
the other to Cryptococcus neoformans. In 1 child progressive multifocal
leukoencephalopathy (PML) coexisted with mycotic encephalitis caused by
an Aspergillus sp.
DE Aspergillosis/PATHOLOGY Aspergillus flavus Autopsy AIDS-Related
Opportunistic Infections/*PATHOLOGY Candidiasis/PATHOLOGY Case Report
Central Nervous System Diseases/*PATHOLOGY Child Child, Preschool
Cytomegalovirus Infections/PATHOLOGY Female Human Infant
Leukoencephalopathy, Progressive Multifocal/PATHOLOGY Male
Mycobacterium avium-intracellulare Infection/PATHOLOGY Support, U.S.
Gov't, P.H.S. JOURNAL ARTICLE REVIEW REVIEW OF REPORTED CASES
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).